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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This article has been cited by other articles in PMC. Abstract During development of a novel treatment for cancer patients, the tumor microenvironment and its interaction with the tumor cells must be considered. Aspects such as the extracellular matrix ECM , the epithelial-mesenchymal transition EMT , secreted factors, cancer-associated fibroblasts CAFs , the host immune response, and tumor-associated microphages TAM are critical for cancer progression and metastasis. Importantly, cytokine overexpression has been linked to drug resistance in cancers and is therefore an attractive target for combinational therapies. Specific inhibitors of cytokines involved in signaling between tumor cells and the microenvironment have not been studied in depth and have great potential for use in personalized medicines.
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Matt Martin - Page 10

She never suspects those heightened reflexes and amazing agility are due to alien DNA, locked away in her system. All seems to be perfect for Nina as she falls in love with her handler and together they go on exotic missions The Webwitch alien race comes to Earth, bringing carnage and death, and activates her as a sleeper agent. Now with her true nature revealed, and a new ability to change into a monster form, Nina is torn between worlds. It is clearly for Mature Readers with gore, nudity, language, adult themes, and all the good stuff that we wish more comics had! If we can hit this goal, we make every copy 64 pages and add in a huge gallery of Matt Martin's Webwitch covers over the years! Printed without logos, every inch to be appreciated, hitting this stretch goal would allow us to add every single one of them to 1!
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